Surprise: Men and Women Are Different
A comparison of cardiac gene expression between all diet combinations together identified a subset of 111 DEGs significant only in males, 64 DEGs significant in females only, and 74 transcripts identified as differentially expressed in response to dietary manipulation in both sexes… Identification of sexual dimorphism in cardiac transcription may provide the basis for sex-specific medicine in the future.
More on gender-specific medicine.
Clinical drug trials tend to use men because men don’t have as many hormones that can cause the results to vary. The downside of using mostly men is that little is known about how hormones affect the response to specific drug therapies in women.
Who is surprised?